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Duehmke, R.M; Hollingshead, J. and Cornblath, D.R (2006) Tramadol for neuropathic pain (Review) Cochrane Database of Systemic Reviews, Issue 3. Art. No. CD003726
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RCVS Controlled Drugs Guidance, Common topics: consolidation of legislation and advice, pp. 11. www.rcvs.org.uk [Accessed: 6/6/18]
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Giorgi, et.al. (2010) ‘Pharmacokinetics of tramadol and metabolites after injective administration in dogs’ Pol.J. Vet. Sci. 13,(4), pp. 639-644
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Seddighi, et.al. (2009) ‘Effects of tramadol on the minimum alveolar concentration of sevoflurane in dogs’ Veterinary Anaesthesia and Analgesia 36, pp. 334-340
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Liu, et.al. (2008) ‘Effect of tramadol on immune responses and nociceptive thresholds in a rat model of incisional pain’ Journal of Zhejiang University 9 (11), pp. 895-902
The first veterinary licensed tramadol
The only veterinary licensed tramadol to have accurate dosing for patients as small as 1.25kg.
Tralieve is an atypical opioid with a dual mechanism of action. It has both mu-opioid effects and effects on pain modulation via action on descending pain pathways. It is indicated for the reduction of acute and chronic mild soft tissue pain (tablets) or for reduction of mild post-operative pain (injection).
How does it work?
Neuropathic pain can be particularly difficult to treat. Tralieve acts on descending pain pathways involved in modulation of neuropathic pain and has been shown to be an effective treatment for neuropathic pain in humans.1
Tralieve is metabolised into several different metabolites. The metabolites with the most analgesic activity is M1, which is 2-4 times more potent than tramadol itself.
Tralieve Tablets
For mild soft tissue and musculoskeletal pain
Tramadol 20 mg and 80 mg tablets
- Flavoured and chewable tablets to enhance compliance
- Available in blister packs which are quick and easy to dispense
- Double divisible for accurate and flexible dosing
- Two strengths to meet the needs of dogs of all sizes
Dosing
Pain management can be complex but with Tralieve, at least dosing different patient sizes is simple. With two, double-divisible tablet sizes you can titrate your doses in increments as small as 5mg and can easily and accurately tailor doses for patients as small as 1.25 kg.
 = 1/4 tablet |
 = 1/2 tablet |
 = 3/4 tablet |
 = 1 tablet |
|---|
| Body weight | Tralieve 20 mg |
|---|---|
| 1.25 kg | |
| 2.5 kg | |
| 3.75 kg | |
| 5 kg | |
| 6.25 kg | |
| 7.5 kg | |
| 10 kg | |
| 15 kg | |
| Body Weight | Tralieve 80 mg |
|---|---|
| 20 kg | |
| 30 kg | |
| 40 kg | |
| 50 kg | |
| 60 kg | |
Click here to download the dosing chart.
Tralieve Injection
For reduction of mild post-operative pain
Tramadol 50 mg/ml solution for injection
- Administered by intramuscular or slow intravenous injection with similar onset time and duration of action by either route
- Onset of action within minutes3
- Reduces MAC of sevoflurane4
- Shows good evidence for effective analgesia5
- 2-4 mg/kg (0.04-0.08ml/kg)
Dosing
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| Body Weight | Tralieve Injection dose volume (4 mg/kg) |
|---|---|
| 5 kg | 0.4 ml |
| 10 kg | 0.8 ml |
| Body Weight | Tralieve Injection dose volume (4 mg/kg) |
|---|---|
| 15 kg | 1.2 ml |
| 20 kg | 1.6 ml |
Using Tralieve responsibly
Tralieve is a Schedule 3 Controlled Drug (CD).
- Prescribe only a reasonable number of tablets at any one time. Recommended maximum of a 1 month supply
- Arrange regular, repeat examinations to monitor the patient and assess response to treatment
- Ensure the client understands the medication
- In accordance with professional, best-practice recommendations, Dechra advise that Schedule 3 drugs are stored in a Controlled Drugs cabinet.
Additional analgesia can be achieved by increasing the Tralieve dose until the maximum daily dose is reached or by following a multi-modal analgesic approach with the addition of other suitable analgesics.
Individual results are variable so you should monitor response carefully.
Even more options for multi-modal analgesia in dogs
Tralieve forms part of Dechra’s comprehensive range of products placed to meet the anaesthetic and analgesic needs of today’s vets. Think of it as a complete pain management system. We can help you to select the products best suited to the animal’s individual needs. We know that anaesthesia and pain management can be complex but, with Dechra, the answer doesn’t have to be.
Dechra provides you with an extensive range of resources to support you with individual cases, to access them click the button below:
Do you need some help?
In case of questions or support, don't hesitate to contact our dedicated support team.
Do you need to talk to the technical support team please give us a call or send us a mail.
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References add